I. Folasaga
Phospholipids o se vasega o lipids o vaega taua o membranes cell ma ei ai se fausaga tulaga ese e aofia ai le ulu hydrophilic ma siʻusiʻu hydrophobic. O le natura amphipathic o phospholipids e mafai ai ona latou fausia lipid bilayers, o le faavae lea o membranes cell. Phospholipids e aofia ai se glycerol backbone, lua fatty acid filifili, ma se phosphate group, faatasi ai ma vaega eseese o loʻo faʻapipiʻi i le phosphate. O lenei fausaga e tuʻuina atu ai i le phospholipids le malosi e faʻapipiʻi ai le tagata lava ia i le lipid bilayers ma vesicles, lea e taua tele mo le amiosaʻo ma le gaioiga o meaola olaola.
E taua tele le sao o Phospholipids i pisinisi eseese ona o a latou meatotino tulaga ese, e aofia ai le emulsification, solubilization, ma le faʻamautuina o aʻafiaga. I totonu o pisinisi taumafa, phospholipids o loʻo faʻaaogaina e fai ma emulsifiers ma stabilizers i meaʻai gaosia, faʻapea foʻi ma meaʻai faʻamalositino ona o latou aoga faʻalesoifua maloloina. I cosmetics, phospholipids e faʻaaogaina mo a latou mea emulsifying ma moisturizing, ma mo le faʻaleleia o le tuʻuina atu o mea aoga i le tausiga o le paʻu ma mea tau tausiga a le tagata lava ia. E le gata i lea, o le phospholipids o loʻo i ai le tele o faʻaoga i vailaʻau, aemaise lava i le tuʻuina atu o vailaʻau ma le faʻatulagaina, ona o lo latou gafatia e faʻapipiʻi ma tuʻuina atu vailaʻau i faʻamoemoega patino i totonu o le tino.
II. Matafaioi a Phospholipids i Mea'ai
A. Emulsification ma fa'amautu meatotino
Phospholipids e avea o ni emulsifiers taua i le alamanuia taumafa ona o lo latou natura amphiphilic. Ole mea lea e mafai ai ona latou fegalegaleai ma le vai ma le suauʻu, e faʻamalosia ai le faʻamautuina o emulsions, e pei o le mayonnaise, salati salati, ma meaʻai susu eseese. O le ulu o le hydrophilic o le phospholipid mole e tosina atu i le vai, ae o le siʻusiʻu o le hydrophobic e faʻafefe ai, e mafua ai le faʻavaeina o se fesoʻotaʻiga mautu i le va o le suauu ma le vai. O lenei meatotino e fesoasoani e puipuia ai le vavaeeseina ma tausia le tufatufaina tutusa o meaʻai i meaʻai.
B. Fa'aoga i le gaosiga ma le gaosiga o mea'ai
Phospholipids o loʻo faʻaaogaina i le gaosiga o meaʻai mo a latou meatotino aoga, e aofia ai lo latou gafatia e faʻaleleia le lanu, faʻaleleia le viscosity, ma maua ai le mautu i meaʻai. E masani ona fa'afaigaluegaina i latou i le gaosiga o mea tao tao, mea suamalie, ma mea tau susu e fa'aleleia atili ai le lelei ma le fa'atumauina o oloa mulimuli. E le gata i lea, o phospholipids o loʻo faʻaaogaina e fai ma mea faʻapipiʻi i le gaosiga o aano o manufasi, moa, ma meaʻai o le sami.
C. Fa'amanuiaga fa'alesoifua maloloina ma fa'aoga mea'ai
Phospholipids e saofagā i le tulaga lelei o meaʻai e pei o mea faʻanatura o le tele o meaʻai, e pei o fuamoa, soya, ma meaʻai susu. O lo'o fa'ailoaina i latou mo a latou fa'amanuiaga fa'alesoifua maloloina, e aofia ai a latou matafaioi i le fausaga ma le fa'aogaina o le telefoni feavea'i, fa'apea fo'i ma lo latou gafatia e lagolago ai le soifua maloloina o le fai'ai ma le gaioiga o le mafaufau. Phospholipids o loʻo suʻesuʻeina foi mo lo latou gafatia e faʻaleleia ai le lipid metabolism ma le soifua maloloina cardiovascular.
III. Fa'aaogāga o Phospholipids i mea teuteu
A. Emulsifying ma moisturizing aafiaga
Phospholipids o loʻo faʻaaogaina lautele i mea teuteu ma mea tau tausiga a le tagata lava ia mo o latou faʻamaʻi ma faʻasusu. Ona o lo latou natura amphiphilic, e mafai e le phospholipids ona fausia ni emulsion mautu, e mafai ai ona faʻafefiloi vai ma mea e faʻavae i luga o le suauu, e maua ai kulimi ma lotions ma lanu lamolemole, tutusa. E le gata i lea, o le fausaga tulaga ese o phospholipids e mafai ai ona latou faʻataʻitaʻiina le paʻu o le lipid masani o le paʻu, faʻaleleia lelei le paʻu ma puipuia le gau o le vai, lea e aoga mo le faʻatumauina o le paʻu o le paʻu ma puipuia le mago.
Phospholipids pei o le lecithin ua faʻaaogaina e fai ma emulsifiers ma moisturizers i le tele o mea teuteu ma paʻu oloa, e aofia ai kulimi, lotions, serums, ma sunscreens. O lo latou gafatia e faʻaleleia ai le tino, lagona, ma mea susu o nei oloa e avea ai i latou ma mea taua i totonu o fale gaosi oloa.
B. Faʻaleleia le tuʻuina atu o mea aoga
E taua tele le sao o le Phospholipids i le faʻaleleia o le tuʻuina atu o mea aoga i mea teuteu ma le tausiga o paʻu. O lo latou gafatia e fausia ai liposomes, vesicles e aofia ai le phospholipid bilayers, e mafai ai ona faʻapipiʻiina ma puipuia mea faʻamalosi, e pei o vitamini, antioxidants, ma isi mea aoga. O lenei fa'apipi'i e fesoasoani e fa'aleleia atili ai le mautu, bioavailability, ma le fa'atatauina o le tu'uina atu o nei vaila'au malosi i le pa'u, fa'aleleia atili ai lo latou aoga i mea teuteu ma le tausiga o pa'u.
E le gata i lea, ua faʻaogaina faiga faʻavae faʻavae phospholipid e foia ai luʻitau o le tuʻuina atu o vailaʻau faʻamalosi hydrophobic ma hydrophilic, ma avea ai i latou ma feʻaveaʻi feʻaveaʻi mo le tele o mea teuteu. Liposomal formulations o lo'o i ai phospholipids ua fa'aaogaina lautele i mea e fa'amasani ai le matua, fa'asusu, ma mea e fa'aleleia ai le pa'u, lea e mafai ai ona latou tu'uina atu mea aoga i le fa'atatauina o pa'u.
C. Matafaioi i le tausiga o pa'u ma oloa tau le tagata lava ia
E taua tele le sao o Phospholipids i le tausiga o le paʻu ma mea tau le tagata lava ia, e fesoasoani i a latou galuega ma aoga. I le faaopoopo atu i lo latou emulsifying, moisturizing, ma le tuʻuina atu-faʻaleleia meatotino, phospholipids e ofoina atu foi faʻamanuiaga e pei o le paʻu paʻu, puipuiga, ma le toe faʻaleleia. E mafai ona fesoasoani nei mole fa'apitoa e fa'aleleia atili le poto masani ma le fa'atinoga o oloa teuteu, ma avea ai ma mea e ta'uta'ua i fa'auiga mo pa'u.
O le fa'aofiina o phospholipids i le tausiga o le pa'u ma mea tau tausiga a le tagata lava ia e fa'alautele atu i tua atu o mea fa'asusu ma kulimi, aua o lo'o fa'aaogaina fo'i i mea fa'amama, fa'aola, fa'amama teuteu, ma mea e teu ai lauulu. O lo latou natura faʻapitoa e mafai ai ona latou faʻafesoʻotaʻi manaʻoga eseese o paʻu ma lauulu, tuʻuina atu faʻamanuiaga faʻalelei ma togafitiga i tagata faʻatau.
IV. Fa'aaogāina ole Phospholipids ile vaila'au
A. Tu'uina atu ma fa'atūina vaila'au
Phospholipids e taua tele i le tuʻuina atu o vailaʻau ma le faʻatulagaina ona o lo latou natura amphiphilic, lea e mafai ai ona latou fausia lipid bilayers ma vesicles e mafai ona faʻapipiʻi uma vailaʻau hydrophobic ma hydrophilic. O lenei meatotino e mafai ai e phospholipids ona faʻaleleia le solubility, mautu, ma le bioavailability o vailaʻau e le mafai ona soluble, faʻaleleia atili ai lo latou gafatia mo le faʻaogaina o togafitiga. E mafai fo'i e faiga tu'uina atu vaila'au fa'avae phospholipid ona puipuia vaila'au mai le fa'aleagaina, fa'atonutonu le fa'asa'olotoina o kinetics, ma fa'atatau i sela ma'oti po'o asi, e saofagā i le fa'aleleia atili o vaila'au ma fa'aitiitia ai a'afiaga.
O le malosi o phospholipids e fausia ai fausaga faʻapipiʻiina e le tagata lava ia, e pei o liposomes ma micelles, ua faʻaaogaina i le atinaʻeina o vailaʻau eseese, e aofia ai le tautala, matua, ma le pito i luga. Lipid-based formulations, e pei o emulsions, solid lipid nanoparticles, ma le tagata lava ia emulsifying drug delivery systems, e masani ona tuʻufaʻatasia phospholipids e faʻatoʻilalo ai luitau e fesoʻotaʻi ma vailaʻau solubility ma absorption, iʻu ai le faʻaleleia o taunuuga togafitiga o oloa vailaʻau.
B. Liposomal faiga tu'uina atu fualaau
Liposomal vaila'au tu'uina atu faiga o se fa'ata'ita'iga iloga o le fa'aogaina o le phospholipids i vaila'au. Liposomes, e aofia ai le phospholipid bilayers, e iai le malosi e faʻapipiʻi ai vailaʻau i totonu o latou aqueous core poʻo lipid bilayers, saunia se siosiomaga puipuia ma pulea le tuʻuina atu o vailaʻau. E mafai ona fetuutuuna'i nei faiga e avatu ai fualaau e fa'aleleia ai le tu'uina atu o ituaiga vaila'au eseese, e aofia ai vaila'au fa'ama'i, vaila'au fa'ama'i, ma tui, e maua ai fa'amanuiaga e pei o le fa'aumiumi o le ta'amilosaga, fa'aitiitia le oona, ma le fa'aleleia atili o le fa'atatauina o masini po'o sela.
O le faʻaogaina o liposomes e mafai ai ona faʻavasegaina o latou lapoʻa, tau, ma mea i luga o le eleele e faʻamalieina ai le utaina o vailaʻau, mautu, ma le tufatufaina atu o aano. O lenei fetuutuuna'i ua mafua ai le atina'eina o liposomal formulations ua faamaonia ile falema'i mo togafitiga eseese, ma faamamafaina ai le taua o le phospholipids i le faʻalauteleina o tekonolosi tuʻuina atu vailaʻau.
C. Fa'aoga talafeagai i su'esu'ega fa'afoma'i ma togafitiga
Phospholipids e mafai ona fa'aogaina mo su'esu'ega fa'afoma'i ma togafitiga i tua atu o faiga masani e tu'uina atu ai vaila'au. O lo latou agava'a e fegalegaleai ai ma pa'u o le sela ma fa'avasegaina fa'agasologa feavea'i e maua ai avanoa mo le atina'eina o ni togafiti fa'afoma'i fou. Phospholipid-based formulations ua suʻesuʻeina mo lo latou gafatia e faʻatatau i auala intracellular, faʻaleleia le faʻaaliga o kene, ma faʻaleleia le aoga o vailaʻau faʻapitoa, faʻaalia le lautele o faʻaoga i vaega e pei o togafitiga faʻafomaʻi, vailaʻau faʻafouina, ma togafitiga o le kanesa.
E le gata i lea, phospholipids ua suʻesuʻeina mo la latou matafaioi i le faʻaleleia o le toe faʻaleleia o le tino ma le toe faʻafouina, faʻaalia le gafatia i le faʻamalolo manuʻa, faʻainisinia o le tino, ma le faʻafouina o vailaʻau. O lo latou agava'a e fa'ata'ita'i ai sela fa'alenatura ma fegalegaleai ma faiga fa'aola e avea ai le phospholipids ma auala fa'amoemoe mo le fa'alauteleina o su'esu'ega fa'afoma'i ma togafitiga.
V. Luitau ma Faatonuga i le Lumanai
A. Iloiloga fa'aletulafono ma popolega mo le saogalemu
O le faʻaaogaina o phospholipids i meaʻai, mea teuteu, ma vailaʻau faʻapitoa e tuʻuina atu ai iloiloga faʻatonutonu ma popolega saogalemu. I totonu o pisinisi taumafa, phospholipids e masani ona faʻaaogaina e fai ma emulsifiers, stabilizers, ma faiga faʻapipiʻi mo mea aoga. O faʻalapotopotoga faʻatonutonu, e pei o le Food and Drug Administration (FDA) i le Iunaite Setete ma le European Food Safety Authority (EFSA) i Europa, latou te vaʻaia le saogalemu ma le faʻailogaina o meaʻai e iai phospholipids. E mana'omia su'esu'ega mo le saogalemu e fa'amautinoa ai o mea'ai fa'aopoopo e fa'atatau i le phospholipid e saogalemu mo le taumafaina ma tausisia tulafono fa'avae.
I totonu o pisinisi teuteu, phospholipids o loʻo faʻaaogaina i le tausiga o le paʻu, tausiga o lauulu, ma mea e teu ai le tagata lava ia mo a latou mea e faʻafefe, susu, ma paʻu paʻu-faʻaleleia meatotino. O ofisa faʻatonutonu, e pei o le European Union's Cosmetics Regulation ma le US Food and Drug Administration (FDA), mataʻituina le saogalemu ma le faʻailogaina o mea teuteu o loʻo iai phospholipids e faʻamautinoa ai le puipuiga o tagata faʻatau. O su'esu'ega mo le saogalemu ma su'esu'ega fa'a'ona o lo'o fa'atinoina e iloilo ai le fa'amatalaga saogalemu o mea e fa'atatau i le phospholipid.
I le vaega o vailaʻau, o le saogalemu ma le faʻatonutonuina o iloiloga o phospholipids e aofia ai lo latou faʻaogaina i faiga faʻapipiʻi vailaʻau, liposomal formulations, ma vailaʻau faʻapitoa. O pulega fa'atulafonoina, e pei o le FDA ma le European Medicines Agency (EMA), iloilo le saogalemu, aoga, ma le lelei o vaila'au o lo'o i ai phospholipids e ala i faiga fa'apitoa ma su'esu'ega fa'afoma'i. O atugaluga mo le saogalemu e fesoʻotaʻi ma phospholipids i vailaʻau faʻapitoa e masani ona faʻataʻamilo i mea oona, immunogenicity, ma le fetaui ma vailaʻau.
B. Tu'u a'e aga ma fa'afouga
O le faʻaaogaina o phospholipids i meaʻai, cosmetics, ma vailaʻau o loʻo feagai ma faiga faʻalauiloa ma atinaʻe fou. I totonu o pisinisi taumafa, o le faʻaaogaina o phospholipids e pei o mea emulsifiers masani ma faʻamautu o loʻo maua le malosi, faʻamalosia e le faʻatupulaia o le manaʻoga mo igoa mama ma meaʻai masani. O tekonolosi fou, e pei o nanoemulsions faʻamautu e phospholipids, o loʻo suʻesuʻeina e faʻaleleia ai le solubility ma le bioavailability o vaega o meaʻai galue, e pei o meaola faʻapitoa ma vitamini.
I totonu o pisinisi teuteu, o le faʻaaogaina o phospholipids i faʻasologa o le tausiga o paʻu o se tulaga iloga, faʻatasi ai ma le taulaʻi atu i faiga faʻavae lipid-faʻavae mo mea aoga ma le toe faʻaleleia o paʻu paʻu. Fuafuaga e aofia ai nanocarriers faʻavae phospholipid, e pei o liposomes ma nanostructured lipid carriers (NLCs), o loʻo faʻalauteleina le aoga ma le faʻatatauina o le tuʻuina atu o mea faʻamalositino, fesoasoani i faʻafouga i le anti-matua, puipuiga o le la, ma mea tau paʻu faʻapitoa.
I totonu o le vaega o vaila'au, o aga fa'atupuina i le tu'uina atu o vaila'au fa'avae phospholipid e aofia ai vaila'au fa'apitoa, togafitiga fa'atatau, ma faiga tu'ufa'atasiga tu'ufa'atasiga o vaila'au. O lo'o fa'atupuina le fa'aleleia atili o le tu'uina atu o tala ma vaila'au o lo'o iai nei, e fa'atatau i lu'itau e feso'ota'i ma le solubility o vaila'au, fa'amautu, ma le fa'atulagaina o nofoaga.
C. Avanoa mo le galulue soosootauau o pisinisi ma avanoa tau atinae
O le faʻaogaina o phospholipids e maua ai avanoa mo le galulue faʻatasi o pisinisi ma le atinaʻeina o oloa fou i le vaeluaga o meaʻai, mea teuteu, ma vailaʻau. O felagolagoma'i fa'asalalau e mafai ona fa'afaigofie ai le fefa'asoaa'i o le poto, tekonolosi, ma faiga sili e feso'ota'i ma le fa'aogaina o phospholipids i vaega eseese. Mo se faʻataʻitaʻiga, o le tomai i le lipid-based system delivery mai le falemaʻi vailaʻau e mafai ona faʻaogaina e faʻaleleia ai le mamanu ma le faʻatinoga o mea e faʻaogaina ai le lipid i meaʻai ma mea teuteu.
E le gata i lea, o le fesoʻotaʻiga o meaʻai, mea teuteu, ma vailaʻau e taʻitaʻia ai le atinaʻeina o oloa faʻapitoa e faʻatatau i le soifua maloloina, soifua maloloina, ma le matagofie. Mo se faʻataʻitaʻiga, nutraceuticals ma cosmeceuticals e aofia ai phospholipids o loʻo aliaʻe ona o se taunuuga o le galulue faʻatasi o pisinisi, ofoina atu fofo fou e faʻaleleia ai le soifua maloloina i totonu ma fafo. O nei feso'ota'iga e fa'atupuina ai fo'i avanoa mo su'esu'ega ma atina'e e fa'atatau i le su'esu'eina o feso'ota'iga talafeagai ma fa'aoga fou o phospholipids i fa'aputuga o oloa fa'apitoa.
VI. Fa'ai'uga
A. Toe fa'afouga o le agava'a ma le taua o phospholipids
Phospholipids e taua tele i pisinisi eseese, e ofoina atu le tele o faʻaoga i meaʻai, mea teuteu, ma vailaʻau. O lo latou fausaga fa'a-kemikolo tulaga ese, lea e aofia uma ai vaega o le hydrophilic ma le hydrophobic, e mafai ai ona latou galulue o ni emulsifiers, stabilizers, ma le tu'uina atu o faiga mo mea aoga. I totonu o pisinisi taumafa, o le phospholipids e fesoasoani i le mautu ma le faʻaogaina o meaʻai gaosi, aʻo i mea teuteu, latou te maua ai le susu, faʻaleleia, ma faʻaleleia le pa puipui i oloa tau paʻu. E le gata i lea, o le falema'i vaila'au e fa'aogaina le phospholipids i le tu'uina atu o vaila'au, liposomal formulations, ma e avea ma vaila'au fa'apitoa ona o lo latou gafatia e fa'aleleia ai le bioavailability ma fa'atatau i nofoaga patino o gaioiga.
B. A'afiaga mo su'esu'ega i le lumana'i ma fa'aoga tau alamanuia
Aʻo faʻaauau pea le alualu i luma o suʻesuʻega i le fanua o phospholipids, o loʻo i ai le tele o aʻafiaga mo suʻesuʻega i le lumanaʻi ma faʻaoga pisinisi. Muamua, o nisi suʻesuʻega i le saogalemu, aoga, ma fesoʻotaʻiga faʻapitoa i le va o phospholipids ma isi mea faʻapipiʻi e mafai ona maua ai le ala mo le atinaʻeina o mea fou e tele galuega e fetaui ma manaoga faʻaleleia o tagata faʻatau. E le gata i lea, o le suʻesuʻeina o le faʻaogaina o phospholipids i faʻasalalauga faʻatekonolosi faʻapitoa e pei o nanoemulsions, lipid-based nanocarriers, ma hybrid lipid-polymer nanoparticles o loʻo i ai le folafolaga mo le faʻaleleia o le bioavailability ma le tuʻuina atu o mea faʻapitoa i meaʻai, mea teuteu, ma vailaʻau. O lenei su'esu'ega e mafai ona ta'ita'ia ai le fa'atupuina o fa'aputuga o oloa fou e maua ai le fa'aleleia atili o le fa'atinoga ma le aoga.
Mai le tulaga tau alamanuia, o le taua o phospholipids i talosaga eseese o loʻo faʻamamafaina ai le taua o le faʻaauau pea o le faʻafouina ma le galulue faʻatasi i totonu ma isi pisinisi. Faatasi ai ma le faatupulaia o manaoga mo mea masani ma aoga, o le tuufaatasia o phospholipids i meaʻai, cosmetics, ma vailaʻau e maua ai se avanoa mo kamupani e atiaʻe ai oloa maualuga, gafataulimaina e ogatusa ma mea e fiafia i ai tagata faatau. E le gata i lea, o le faʻaogaina o pisinisi i le lumanaʻi o phospholipids e mafai ona aofia ai faiga faapaaga faʻasalalau, lea e mafai ai ona fesuiaʻi le malamalama ma tekinolosi mai meaʻai, mea teuteu, ma fale talavai e fausia ai ni mea fou, tele galuega e ofoina atu le soifua maloloina atoa ma le matagofie.
I le faaiuga, o le faʻaogaina o phospholipids ma lo latou taua i meaʻai, mea teuteu, ma vailaʻau faʻapitoa e avea ai ma vaega taua o le tele o oloa. O latou gafatia mo suʻesuʻega i le lumanaʻi ma faʻaoga faʻapisinisi e faʻaavanoaina ai le auala mo le faʻaauauina o le alualu i luma i mea faʻapitoa ma faʻaogaina fou, faʻatulagaina le laufanua o le maketi o le lalolagi i pisinisi eseese.
Fa'asinomaga:
1. Mozafari, MR, Johnson, C., Hatziantoniou, S., & Demetzos, C. (2008). Nanoliposome ma a latou faʻaoga i meaʻai nanotechnology. Journal of Liposome Research, 18(4), 309-327.
2. Mezei, M., & Gulasekharam, V. (1980). Liposomes - O se faiga e tu'uina atu vaila'au filifilia mo le auala autu o le pulega. Fuga fa'ainu vai. Life Sciences, 26(18), 1473-1477.
3. Williams, AC, & Barry, BW (2004). Fa'apena fa'apena. Fa'amatalaga Tu'uina Atu Vailaau Mata'utia, 56(4), 603-618.
4. Arouri, A., & Mouritsen, OG (2013). Phospholipids: tupuaga, biochemistry ma auiliiliga. Tusitaulima o hydrocolloids (Lomiga Lona Lua), 94-123.
5. Berton-Carabin, CC, Ropers, MH, Genot, C., & Lipid Emulsions ma a latou Fa'atulagaga - Journal of Lipid Research. (2014). mea emulsifying o mea'ai-grade phospholipids. Journal of Lipid Research, 55(6), 1197-1211.
6. Wang, C., Zhou, J., Wang, S., Li, Y., Li, J., & Deng, Y. (2020). Fa'amanuiaga fa'alesoifua maloloina ma fa'aogaina o phospholipids fa'anatura i mea'ai: O se Iloiloga. Innovative Food Science & Emerging Technologies, 102306. 8. Blezinger, P., & Harper, L. (2005). Phospholipids i mea'ai aoga. I Mea'ai Modulation o Cell Signaling Pathways (itulau 161-175). CRC Press.
7. Frankenfeld, BJ, & Weiss, J. (2012). Phospholipids i mea'ai. I Phospholipids: Faʻamatalaga, Metabolism, ma Novel Biological Applications (itulau 159-173). AOCS Press. 7. Hughes, AB, & Baxter, NJ (1999). Emulsifying meatotino o phospholipids. I Mea'ai emulsions ma foams (itulau 115-132). Royal Society of Chemistry
8. Lopes, LB, & Bentley, MVLB (2011). Phospholipids i faiga tu'uina atu cosmetic: saili mo le mea sili mai le natura. I Nanocosmetics ma nanomedicines. Springer, Perelini, Heidelberg.
9. Schmid, D. (2014). Le matafaioi o phospholipids faanatura i cosmetics ma tausiga patino. In Advances in Cosmetics Science (itulau 245-256). Springer, Cham.
10. Jenning, V., & Gohla, SH (2000). Fa'asalaina o retinoids i totonu o le lipid nanoparticles (SLN). Journal of Microencapsulation, 17 (5), 577-588. 5. Rukavina, Z., Chiari, A., & Schubert, R. (2011). Faʻaleleia mea faʻalelei e ala i le faʻaaogaina o liposomes. I Nanocosmetics ma nanomedicines. Springer, Perelini, Heidelberg.
11. Neubert, RHH, Schneider, M., & Kutkowska, J. (2005). Phospholipids i cosmetics ma pharmaceutical sauniuniga. In Anti-Aging in Ophthalmology (itulau 55-69). Springer, Perelini, Heidelberg. 6. Bottari, S., Freitas, RCD, Villa, RD, & Senger, AEVG (2015). Fa'aoga autu o phospholipids: o se fuafuaga fa'amoemoe e toe fa'aleleia le pa'u o le pa'u. Fuafuaga Falema'i o lo'o iai nei, 21(29), 4331-4338.
12. Torchilin, V. (2005). Tusitaulima o pharmacokinetics taua, pharmacodynamics ma fualaau faasaina metabolism mo saienitisi alamanuia. Springer Science & Faasalalauga Pisinisi.
13. Aso, AA, & Nagarsenker, M. (2008). Fuafuaga ma le iloiloga o faiga e tuʻuina atu ai fualaau faʻasaina (SEDDS) o nimodipine. AAPS PharmSciTech, 9(1), 191-196.
2. Allen, TM, & Cullis, PR (2013). Liposomal vaila'au tu'uina atu faiga: Mai manatu i le falema'i talosaga. Fa'amatalaga Tu'uina atu o Vailaau Fa'apitoa, 65(1), 36-48. 5. Bozzuto, G., & Molinari, A. (2015). Liposome e fai ma masini nanomedical. International Journal of Nanomedicine, 10, 975.
Lichtenberg, D., & Barenholz, Y. (1989). Liposome vailaʻau' lelei utaina: o se faʻataʻitaʻiga galue ma lona faʻataʻitaʻiga faʻamaonia. Tu'uina atu Vailaau, 303-309. 6. Simons, K., & Vaz, WLC (2004). Fa'ata'ita'iga faiga, lipid rafts, ma sela sela. Iloiloga Faaletausaga o Biophysics ma Biomolecular Structure, 33(1), 269-295.
Williams, AC, & Barry, BW (2012). Fa'apena fa'apena. I Dermatological Formulations: Percutaneous Absorption (itulau 283-314). CRC Press.
Muller, RH, Radtke, M., & Wissing, SA (2002). Lipid nanoparticles (SLN) ma nanostructured lipid carriers (NLC) i teuteuga ma dermatological sauniuniga. Fa'amatalaga Tu'uina Atu Vailaau Mata'utia, 54, S131-S155.
2. Severino, P., Andreani, T., Macedo, AS, Fangueiro, JF, Santana, MHA, & Silva, AM (2018). Fa'aonaponei fa'aonaponei ma aga fou i luga o le lipid nanoparticles (SLN ma le NLC) mo le tu'uina atu o vaila'au fa'afofoga. Journal of Drug Delivery Science and Technology, 44, 353-368. 5. Torchilin, V. (2005). Tusitaulima o pharmacokinetics taua, pharmacodynamics ma fualaau faasaina metabolism mo saienitisi alamanuia. Springer Science & Faasalalauga Pisinisi.
3. Williams, KJ, & Kelley, RL (2018). Fa'atekonolosi fa'atekonolosi fa'apisinisi. John Wiley & Atalii. 6. Simons, K., & Vaz, WLC (2004). Fa'ata'ita'iga faiga, lipid rafts, ma sela sela. Iloiloga Faaletausaga o Biophysics ma Biomolecular Structure, 33(1), 269-295.
Taimi meli: Tes-27-2023
